Paper Submission: 27 January 2021
Author Notification: 7 to 10 days
Journal Publication: January 2021
Martin L. Pall
Dozens of reviews and thousands of primary literature studies have shown the existence of many different non-thermal health effects of microwave and lower frequency electromagnetic fields (EMFs); however current safety guidelines and standards only recognize thermal effects. This leaves both individuals and companies unprotected, particularly with the very large increases in microwave frequency exposures that are occurring over time. It has recently been shown that many, perhaps even all non-thermal health effects are produced by activation of voltage-gated calcium channels (VGCCs) in the plasma membranes of cells, with EMFs activating these channels, producing large increases in intracellular calcium levels [Ca2+]i. The voltage sensor controlling the VGCCs is thought to be extremely sensitive to activation by weak EMFs. Diverse health effects are thought to be produced by downstream effects of increased [Ca2+]i produced by VGCC activation. It is difficult if not impossible to currently predict the biological effects of different EMFs because pulsation patterns, frequencies and EMF polarization each have strong influences on biological effects; there are also windows of exposure producing maximum biological effects within the exposure window. While decreasing exposures on the order of 100 to 1000-fold will no doubt be useful, we also need to have genuine biological measures of damage to allow optimization of both the type of EMF exposures as well as intensities. Biological optimization should be done by studying cells in culture that have high densities of various types of VGCCs, measuring such effects as increases in [Ca2+]i and increases in nitric oxide (NO) production following EMF exposures. Such cell culture-based assessment of biological damage should allow progressive improvement of wireless communication devices and various other electronic devices by choosing designs that lower biological responses.
 Naval Medical Research Institute Research Report, June 1971. Bibliography of Reported Biological Phenomena (“Effects”) and Clinical Manifestations Attributed to Microwave and Radio-Frequency Radiation. Report No. 2 Revised.
 Pall, M. L. 2015. Microwave frequency electromagnetic fields (EMFs) produce widespread neuropsychiatric effects including depression. J. Chem. Neuroanat. 2015 Aug 20. pii: S0891-0618(15)00059-9.doi: 10.1016/j.jchemneu.2015.08.001. [Epub ahead of print] Review.
 Tolgskaya, M. S., Gordon, Z. V. 1973. Pathological Effects of Radio Waves, Translated from Russian by B Haigh. Consultants Bureau, New York/London, 146 pages.
 Raines, J. K. 1981. Electromagnetic Field Interactions with the Human Body: Observed Effects and Theories. Greenbelt, Maryland: National Aeronautics and Space Administration 1981; 116 p.
 Bolen, S. M. 1994 Radiofrequency/Microwave Radiation Biological Effects and safety standards: a review. AD-A282 886, Rome Laboratory, U.S. Air Force Material Command, Griffiss Air Force Base, New York.
 Havas, M. 2013. Radiation from wireless technology affects the blood, the heart, and the autonomic nervous system. Rev. Environ. Health. 28(Nov 2013), 75-84.
 Adams, J. A., Galloway, T. S., Mondal, D., Esteves, S. C. 2014 Effect of mobile telephones on sperm quality: A systematic review and meta-analysis. Environment. Int. 70, 106- 112.
 Adey, WR. 1993 Biological effects of electromagnetic fields. J Cell Biochem 51:410-416.
 Adey W. R. 1981 Tissue interactions with nonionizing electromagnetic fields. Physiol. Rev. 61, 435-514.
 Dumanskij, J. D., and Shandala, M. G., 1974. The biologic action and hygienic significance of electromagnetic fields of super-high and ultrahigh frequencies in densely populated areas. Effects and Health Hazards of Microwave Radiation, Proceedings of an International Symposium, Warsaw, 15-18 Oct. 1973, P. Czerski et al., eds.
 Dwyer, M. J., Leeper, D. B. 1978 A Current Literature Report on the Carcinogenic Properties of Ionizing and Nonionizing Radiation. DHEW Publication (NIOSH) 78-134, March 1978.
 Frey, A. H. 1998. Headaches from cellular telephones: are they real and what are the implications? Environ. Health Perspect. 106, 101-103.
 Khurana, V. G., Hardell, L., Everaert, J., Bortkiewicz, A., Carlberg, M., Ahonen, M. 2010. Epidemiological evidence for a health risk from mobile phone base stations. Int. J. Occup. Environ. Health 16, 263-267.
 Lai, H. 1997. Neurological effects of radiofrequency electromagnetic radiation relating to wireless communication technology. Paper presented at the IBC-UK Conference: “Mobile Phones – Is There a Health Risk?” www.papcruzin.com/radiofrequency/henry_lai1.htm
 Lerner, E. J. 1980. RF radiation: Biological effects. IEEE Spectrum 17(Dec 1980), 51-59.
 Fragopoulou A, Grigoriev Y, Johansson O, Margaritis LH, Morgan L, Richter E, Sage C. 2010. Scientific panel on electromagnetic field health risks: consensus points, recommendations, and rationales. Rev. Environ. Health 25, 307- 317.
 Levitt, B. B., Lai, H. 2010. Biological effects from exposure to electromagnetic radiation emitted by cell towers base stations and other antenna arrays. Environ. Rev. 18, 369- 395.
 Murbach, M., Neufeld, E., Christopoulou, M., Achermann, P., Kuster, N. 2014. Modeling of EEG electrode artifacts and thermal ripples in human radiofrequency exposure studies. Bioelectromagnetics 35, 273-283.
 Walleczek, J. 1992. Electromagnetic field effects on cells of the immune system: the role of calcium signaling. FASEB J. 6, 3177-3185.
 Yakymenko, I., Sidorik, E., Kyrylenko, S., Chekhun, V. 2011. Long-term exposure to microwave radiation provokes cancer growth: evidences from radars and mobile communication systems. Exp. Oncol. 33(2), 62-70.
 Herbert, M. R., Sage, C. 2013 Autism and EMF? Plausibility of a pathophysiological link – Part I. Pathophysiology 20, 191-209.
 Herbert, M. R., Sage, C. 2013. Autism and EMF? Plausibility of a pathophysiological link part II. Pathophysiology 20, 211-234.
 Pall, M. L. 2015. Scientific evidence contradicts findings and assumptions of Canadian Safety Panel 6: microwaves act through voltage-gated calcium channel activation to induce biological impacts at non-thermal levels, supporting a paradigm shift for microwave/lower frequency electromagnetic field action. Rev. Environ. Health 3, 99-116.
 Panagopoulos, D. J., Johansson, O., Carlo, G. L. 2015. Real versus simulated mobile phone exposures in experimental studies. BioMed. Res. Int. 2015, article ID 607053, 8 pages.
 Pilla, A. A. 2013 Nonthermal electromagnetic fields: from first messenger to therapeutic applications. Electromagn. Biol. Med. 32, 123-136.
 Markov, M. S., Ed. 2015. Electromagnetic Fields in Biology and Medicine. CRC Press, Taylor and Francis Group, Boca Raton, FL.
 Belyaev, I. 2015. Biophysical mechanisms for nonthermal microwave effects. In: Electromagnetic Fields in Biology and Medicine, Marko S. Markov, ed, CRC Press, New York, pp 49- 67.
 Panagopoulos, D. J., Johansson, O., Carlo, G. L. 2013. Evaluation of specific absorption rate as a dosimetric quantity for electromagnetic fields bioeffects. PloS ONE 8(6): e62663. doi:10:1371
 Pall, M. L. 2013. Electromagnetic fields act via activation of voltage-gated calcium channels to produce beneficial or adverse effects. J. Cell. Mol. Med. 17,958-965.
 Sheppard, A. R., Swicord, M. L., Balzano, Q. 2008. Quantitative evaluations of mechanisms of radiofrequency interactions with biological molecules and processes. Health Phys. 95, 365-396.
 Canadian Royal Society Expert Panel Report on Radiofrequency Fields. 2014. https://rscsrc.ca/sites/default/files/pdf/SC6_Report_Formatted_1.pdf (accessed July 14, 2014).
 Pilla, A. A. 2012. Electromagnetic fields instantaneously modulate nitric oxide signaling in challenged biological systems. Biochem. Biophys. Res. Commun. 426, 330-333.
 Hardell, L., Sage, C. 2008. Biological effects from electromagnetic field exposure and public exposure standards. Biomed. Pharmacother. 62, 104-109.
PhD, Professor Emeritus of Biochemistry and Basic Medical Sciences, Washington State University 638 NE 41st Ave., Portland, OR 97232, USA Phone: 503-232-3883 email@example.com
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