Origin of the Human Genome Project

Dr. Jayakrishna Herur

Abstract

The latter part of the twentieth century and the early years of the twenty-first century saw unprecedented advances in biomedical research. The structure of the DNA double helix was discovered in 1953. Watson and Crick, 1953. About fifty years later, scientists in the Human Genome Project HGP finished genome sequencing, offering a comprehensive roadmap to the locations of the roughly 30,000 human genes an occasion lauded by special editions of the magazines Nature and Science. The decoding of the human genome is likely to go down as one of the most momentous breakthroughs in scientific history; nonetheless, it is evident that the genomic knowledge has not resulted in solutions to the numerous concerns regarding the hereditary basis of illness. The genome sequence may be considered as a dictionary, providing researchers with the foundation required to fill out the grammar and syntax of disease language. When the project was nearing completion, National Human Genome Research Institute director Francis Collins 2001 stated, the end of the beginning. the true payoff from the HGP will be the ability to diagnose, treat, and prevent disease, and most of those benefits to humanity still lie ahead. The genome sequencing data will be utilised to learn about individual human genetic variants. The quantity of genetic variation, or polymorphism, between humans remains unclear, as is the amount of variation gained as we age.